# \[e-drug\] ADRs and cox 2 inhibitors **URL:** \ **Category:** e-drug\ **Created:** [August 25, 2000, 1:46am UTC](https://talk.edrugplus.org/t/e-drug-adrs-and-cox-2-inhibitors/9001 "2000-08-25T01:46:43Z")\ **Posts on this page:** 1\ **Page:** 1
**Author:** ![Jody\_Dalmacion](https://avatars.discourse-cdn.com/v4/letter/j/9dc877/32.png) [@Jody\_Dalmacion](https://talk.edrugplus.org/u/Jody_Dalmacion)\ **Post date:** [August 25, 2000, 1:46am UTC](https://talk.edrugplus.org/t/e-drug-adrs-and-cox-2-inhibitors/9001/1 "2000-08-25T01:46:43Z")
E-drug: ADRs and cox 2 inhibitors --------------------------------------------- August 24,2000 May I know if any e-druggers have any information about the incidence of bleeding from the cox2 inhibitors like vioxx? I am asking this because of a recent incident that happened in our hospital involving a 15 yr old male patient who underwent an emergency exploratory lap for abdominal pain which was diagnosed as acute appendicitis. Postop, he was given vioxx for pain control. He developed rashes thereafter but was sent home still on vioxx as home med. He was brought back to the emergency room the next day where he was managed as a case of anaphylaxis. He eventually expired after rescuscitative measures failed. Autopsy report showed pulmonary hemorrhage. The ADR subcommittee met to discuss the case but representative of the allergy section thinks it was a case of Henoch Schonlein which can present as abdominal pain. (Histopath of appendix showed only congestion). However, with recent reports from Australia about gastrointestinal bleeding occuring more frequently with the cox 2 inhibitors than expected, I maintained my opinion that we cannot rule out ADR to vioxx in this instance. I would appreciate any additional or related information from the group. Jody Dalmacion Jody Vergeire-Dalmacion,MD Associate Professor Department of Pharmacology, UP College of Medicine Philippines e-mail:jrvd1257@yahoo.com -- Send mail for the `E-Drug' conference to `e-drug@usa.healthnet.org'. Mail administrative requests to `majordomo@usa.healthnet.org'. For additional assistance, send mail to: `owner-e-drug@usa.healthnet.org'.