# \[e-drug\] Association Diclofenac/Misoprostol (cont) **URL:** \ **Category:** e-drug\ **Created:** [January 26, 2001, 3:01am UTC](https://talk.edrugplus.org/t/e-drug-association-diclofenac-misoprostol-cont/10169 "2001-01-26T03:01:33Z")\ **Posts on this page:** 1\ **Page:** 1
**Author:** ![Randy\_Trinkle](https://avatars.discourse-cdn.com/v4/letter/r/ecae2f/32.png) [@Randy\_Trinkle](https://talk.edrugplus.org/u/Randy_Trinkle)\ **Post date:** [January 26, 2001, 3:01am UTC](https://talk.edrugplus.org/t/e-drug-association-diclofenac-misoprostol-cont/10169/1 "2001-01-26T03:01:33Z")
E-drug: Association Diclofenac/Misoprostol (cont) ---------------------------------------------\> > a) Is there an association like this in your countries? yes (Canada) > b) If the previous answer is positive: Which are the legal restrictions? It's a prescription-only drug - otherwise no restrictions. > c) Is there a really necessity for this combination, or there is other solution to minimize gastrointestinal AE of NSAIDs? Misoprostol is not the only agent to prophylaxis against NSAID- induced ulcers. Proton pump inhibitors also provide this protection. Some clinicians have found the same to be true for high doses of famotidine. So - is this particular combination "necessary"? Depends on your desired endpoint. Not everyone develops an ulcer. Misoprostol reduces the risk. > d) Do you know about the illegal use of this drug in your counties, > i.e. as an abortifacient? Using misoprostol as an abortifacient is not illegal in Canada. It's simply not an approved indication in the official monograph. Therefore this is an off-label use. I've never heard of it being used alone for this purpose but only in combination with methotrexate - which is a well-studied use of the drug. Randy Trinkle, BScPharm BA Clinical Pharmacist Prince Rupert Regional Hospital Prince Rupert, BC Health Science Links: [http://www.rupert.net/~rtrinkle](http://www.rupert.net/~rtrinkle) [mailto:rtrinkle@mail.citytel.net](mailto:rtrinkle@mail.citytel.net) -- Send mail for the `E-Drug' conference to `e-drug@usa.healthnet.org'. Mail administrative requests to `majordomo@usa.healthnet.org'. For additional assistance, send mail to: `owner-e-drug@usa.healthnet.org'.