E-DRUG: Help wanted: aspirin dose
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Hi Everyone
Can anyone help, please?
We have a 10 month old baby with a right internal capsule infarct.
Doctors wish to use aspirin for its antiplatelet effect. Looking
for a dose ( with reference). Drugdex has 1-2mg/kg/day. Another
textbook has 2-5mg/kg/day without a reference. Can anyone help
with a substantial answer?
Thanks
Joe Talmud
Drug Info Pharmacist
Medicines Information Centre
Dept Pharmacology
UCT Medical School
K Floor, Old Main Building, Groote Schuur Hospital,
Observatory 7925
South Africa
Phone: 021-4066427
e-mail: jtalmud@uctgsh1.uct.ac.za
Note from the moderator:
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Here are few references from Medline which may be relevant:
Jafri SM. The role of antiplatelet therapy in acute coronary
syndromes and for secondary prevention following a myocardial
infarction. Prog Cardiovasc Dis 36(1), 75-83 (1993)
LeBlanc JG. Antiplatelet therapy in children with left-sided
mechanical prostheses. Eur J Cardiothorac Surg 7(4), 211-215 (1993)
Hathaway WE. Use of antiplatelet agents in pediatric
hypercoagulable states. Am J Dis Child 138(3), 301-304 (1984)
Schmidt B. Inhibition of platelet function in pediatric medicine.
Klin Padiatr 194(2), 91-93 (1982)
Breddin K. Use of platelet inhibitor drugs in peripheral and
cerebral vascular disorders. Bibl Haematol 44, 197-205 (1977)
Please note: the use of aspirin in children as a general analgesic
or antipyretic is not recommended by some authorities. Aspirin use
has been associated with Reye's syndrome, a severe but rare disorder
characterized by acute encephalopathy and liver degeneration.
Syed Rizwanuddin Ahmad
Email: ra@usp.org
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