# E-DRUG: rationale of dexamethasone combination?

**URL:** https://talk.edrugplus.org/t/e-drug-rationale-of-dexamethasone-combination/1770
**Category:** e-drug
**Created:** [December 7, 1997, 3:34pm UTC](https://talk.edrugplus.org/t/e-drug-rationale-of-dexamethasone-combination/1770 "1997-12-07T15:34:51Z")
**Posts on this page:** 1
**Page:** 1

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### Author: ![Gaut\_Gadeholt1](https://avatars.discourse-cdn.com/v4/letter/g/ba9def/32.png) [@Gaut\_Gadeholt1](https://talk.edrugplus.org/u/Gaut_Gadeholt1)
#### Post date: [December 7, 1997, 3:34pm UTC](https://talk.edrugplus.org/t/e-drug-rationale-of-dexamethasone-combination/1770/1 "1997-12-07T15:34:51Z")

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E-DRUG: rationale of dexamethasone combination? (3)  
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The stage one answer: The European Union rules require that all active  
drugs in a combination preparation shall participate in the  
therapeutic effect. This rules out the vitamins. They have no  
proven therapeutic effect in the condition to be treated.

Corticosteroids (dexamethasone) are inappropriate for such  
trivial conditions as myalgia, bursitis, headache.

The whole idea of nonsteroidal anti-inflammatory drugs is to  
avoid steroids. For this reason, combination of a steroid and a  
nonsteroid anti-inflammatory drug is less than rational.

And how about the relative amounts?

And finally: Dexamethasone has so long half-life that dosing 3-4  
times daily is ridiculous.

Gaut Gadeholt  
Email: gaut@online.no

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