E-DRUG: RFI: side effect of sulbactam (2)
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May I know what is the side effect of sulbactam if given overdose? and
what is the rationale requiring dosage adjustment of sulbactam in renal
impairment?
Dear Chee Lan,
Do you have access to Micromedex or Martindale?
Tthe following info for sulbactam as per Micromedex:
4.1.1 THERAPEUTIC
A. Clinical signs and symptoms of infection
B. Fever
C. WBC count
D. Culture and sensitivities as indicated
4.1.2 TOXIC
A. Diarrhea
B. Skin rash
C. Hematologic studies (RBC, CBC with differential, platelets)
Sulbactam is eliminated primarily via urinary excretion, and appears to be
secreted by the renal tubules (Foulds, 1986; Brown et al, 1982; Rogers et
al, 1983; Caine et al, 1984). Approximately 75% of an administered dose of
sulbactam is recovered in the urine as unchanged drug (Foulds et al, 1983).
Rgds
Kenneth Ch'ng
Australia
Kenneth.Chng@wghg.com.au
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