E-DRUG: Beyond WHO Stop TB?
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[Here is a serious issue: are WHO's Stop TB policies sufficient to protect
us from the exploding MDR and XDR-TB epidemics?
MDR- and XDR-TB are spreading as a nosocomial infection among HIV+
communities. Genevea, we have a problem...
E-drug does not cover TB drug policies very much; seems that the TB
community is gathered elsewhere. What can we do?
Copied as fair use. WB]
http://www.health-e.org.za/news/article.php?uid=20031622
WHO TB Strategy out of reach for many endemic countries
By Dr Bobby John and Dr Tim France
23.03.2007
A much larger TB drug resistance problem exists than researchers previously
thought. New global data on TB, published this week by the World Health
Organization (WHO), highlight serious weaknesses in many national TB
programmes, increasing the potential for widespread TB drug resistance. How
did we reach this precarious state?
Ask a WHO expert that question and they assert that increasing levels of TB
drug resistance: "reflects a failure to implement the WHO Stop TB Strategy."
The strategy hopefully maps out the steps that national TB control
programmes need to take. By all accounts then, our national TB programmes
are failing us.
The bacterium that causes tuberculosis (TB), Mycobacterium tuberculosis, is
naturally sensitive to the antibiotic drugs used to treat the disease. The
accepted truth about how TB drug resistance starts is that it is mostly
'acquired' in individual patients, because of inadequate treatment with TB
drugs, now at least 40 years old.
Poor patient drug adherence, or the use of too few drugs leads - the story
goes - to various forms of drug resistant TB. Multidrug-resistant TB
(MDR-TB) is a specific type that does not respond to the two most powerful
anti-TB drugs. Latest estimates are that MDR-TB makes up about 4% of all new
and previously-treated TB globally. Apparently, our antiquated TB drugs are
failing us too.
Drug resistant TB is already geographically widespread, including in places
where TB control programmes have been in place for many years. But
incredibly little is known about just how much TB drug resistance there is
outside of capital cities, for example, and even in some entire countries
where drug resistance may be common because of historically poor TB control.
No progress can be made if the TB clinics are there but the patients are
not. Today's standard test for TB relies on a technique (sputum microscopy)
invented over a hundred years ago. It provides no information about drug
resistance. Apparently TB diagnosis is also failing us.
Too many weak points to deal with? A further litany of vital TB programme
components has also been ignored for years, in favour of a single jewel in
the TB strategy's crown: directly-observed treatment short course, or DOTS.
In many places, a consistent lack of focus and investment has led to:
* Chronically weak TB diagnostic and laboratory services;
* Infrequent and incomplete TB drug resistance surveillance;
* Inadequate management of individual drug resistant TB cases;
* Paltry TB infection control measures, including in health care settings.
Predictably, many TB-endemic countries have indeed failed to meet the
exacting standards of the WHO Stop TB Strategy. Given the circumstances in
many countries where TB is rife, what is surprising is that they should be
asked to pursue such a pipedream.
DOTS was supposed to stem TB drug resistance. Because of sloppy and
unimaginative implementation, it is evidently failing us. As the full extent of
TB drug resistance comes to light, prioritising TB drug delivery above all
other areas of TB diagnosis and care looks increasingly like WHO has been
building a house, just without foundations. We cannot now claim to be
surprised when a decade of overlooking the systemic challenges faced by high
TB countries brings the entire house tumbling down.
Promoting policy frameworks is no replacement for working together to
achieve what needs to be done to address TB. The Global Plan to Stop TB,
(2006-2015), launched by the Stop TB Partnership just over a year ago, is a
road map for such a coordinated action.
WHO urgently needs to look beyond 'their' Stop TB Strategy to help promote
and coordinate the comprehensive range of actions set out in the Plan - and
to recognise the track record of over five hundred global partners who put
their name behind it.
When she took office just a few months ago, the new WHO Director-General, Dr
Margaret Chan, identified the organisation's many partnerships as one of her
immediate priorities. "Either the partnerships have to change or we have to
change or both of us have to change to be more relevant," she said. "What is
important to me is, are we getting the results that matter?"
In the case of controlling TB drug resistance, the answer is an unequivocal
'no'.
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Bobby John, MBBS, is the Executive Director of the Center for Sustainable
Health & Development, India, and President of Global Health Advocates
(www.ghadvocates.org). [Please contact Ranjit Monga (+9198112 07293) or
Parul Chand (+919811210418) at brightlite@brightliteonline.com]
Tim France, PhD, is Technical and Policy Adviser to Health & Development
Networks (www.hdnet.org), and Chairman of the Stop TB Partnership
(www.stoptb.org) Media and Events Task Force. [Please contact Bobby Ramakant
(bobby@hdnet.org or mobile: +919839073355]