E-drug: Differences in use, if any, between benzylpenicillins
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Dear e-druggers,
Could someone help me with the association between benzathine
benzylpenicillin and procaine benzylpenicillin.
If used together, is this association compatible?
Is it currently used? In what situation (diseases, infections)?
Is there any advantage?
I thank in advance.
Sincerely,
EM�LIA VIT�RIA SILVA
Pharmacist
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Em�lia Vit�ria Silva
Centro Brasileiro de Informa��es sobre Medicamentos - Cebrim
Conselho Federal de Farm�cia - CFF
SCRN 712/13 Bloco G n� 30 - Bras�lia-DF - 70.760-770 Brasil
Fone: 55 (061) 349-6552 Fax: 55 (061) 349-6553
E-mail: cebrim@cff.org.br - Home-page: http://www.cff.org.br
[Note from moderator: The first question is not all clear to me. You would
not use the two long-acting together, but combinations of benzylpenicillin
and the long-acting procaine, resp. benzathine are used. Except in STD's
where benzathine benzylpenicillin is used to ensure compliance (you give one
dose and then you know the patient got it) I see few uses. By using
long-acting penicillins concentrations will be low and unpredictable (NB
risk of developing resistance). In most cases oral phenoxymethylpenicillin
will be preferable. If the patient is so sick that oral medication cannot be
used, in my view benzylpenicillin should be used i.v. High use of injectable
drugs is a bad habit and should be discouraged. KM]
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