E-DRUG: Excellent systematic review on neuraminidase inhibitors
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[E-drug is informed that WHO will assess this new publication (although it does not actually contain new trials, the BMJ meta analysis is a reanalysis of some but not all of the trials in the previous version) at the next meeting of the guideline panel on antivirals, as well as at a special emergency session of the Expert Committee
(see http://www.who.int/selection_medicines/committees/expert/emergency_session/en/index.html ) in January 2010. ]
Dear E-druggers
A series of systematic review on the efficacy and safety on neuraminidase
inhibitors in the current issue of BMJ is very excellent and timely.
http://www.bmj.com/
And yet I have several comments on these reports especially on the
harmful effects of NSAIDs and oseltamivir.
I have posted three rapid responses to this issue since just before
they appeared and will more within a few days.
The first one is before the series appeared:
1. Early use of oseltamivir: a case of respiratory depression after
each of two doses, with sudden death. Rapid response: http://www.bmj.com/cgi/e
letters/339/nov13_2/b4831#227027
The second one is (this and the followings are the responses to the
series):
2. response to the main paper (by Tom Jefferson et al)
"Oseltamivir: psychotic and neurological adverse reactions in the
randomized controlled trials"
http://www.bmj.com/cgi/eletters/339/dec07_2/b5106#227187
3. rapid response to the review paper on the observational studies
(by Freemantle and Calvert)
What can we learn from observational studies of oseltamivir without examining
NSAIDs use?
at: http://www.bmj.com/cgi/eletters/339/dec07_2/b5248#227268
Please look at it and I hope you to make rapid responses to them.
This is now of the most important issues in treating
09AH1N1 influenza and seasonal influenza as well.
Best regards
Kusuri-no-Check
Rokuro Hama
HAMA, Rokuro MD Chairperson "Kusuri-no-Check"
NPOJIP: Non-Profit Organization "Japan Institute of Pharmacovigilance"
publishing ISDB-full-membership Drug Bulletin
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