E-DRUG: Independent Drug and Healthcare Newsletter for February 2021
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Newsletter, February 2021
Independtnt information by and for healthcare professionals
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In Prescrire's Spotlight this month :
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DRUGS TO AVOID - 2021 UPDATE
Prescrire publishes its annual update of drugs to avoid, in the name of better patient care
For the ninth consecutive year, independent French medical journal Prescrire has published its annual update of drugs to avoid. The goal is to make it easier to choose high-quality care, and to prevent disproportionate harm to patients.
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FEATURED REVIEW
Ebola vaccine rVSV-Zebov (Ervebo°) in an outbreak of Ebola virus disease. Major reduction in incidence among those at risk for this often-fatal infection. Ebola virus disease is a contagious and often fatal infection for which there was no vaccine or cure. According to two clinical trials, the live attenuated vaccine, Ebola vaccine rVSV-Zebov, confers high levels of protection to people who come into contact with infected patients.
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FREE DOWNLOAD
Liposomal forms of drugs
Healthcare professionals must take great care at every stage of the medication-use process when dealing with drugs that are available in liposomal and non-liposomal forms.
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NEWS UPDATE
The covid-19 messenger RNA vaccine from Moderna: as with the tozinameran vaccine (Comirnaty°, Pfizer/BioNTech), limited data and unanswered questions. As of early January 2021, the covid-19 vaccine mRNA-1273 Sars-CoV-2, from the pharmaceutical company Moderna, is expected to be approved for use in the European Union. In France, this vaccine is to be offered first to elderly residents of nursing homes and similar facilities, and to certain health professionals.
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EDITORIAL
Like any other drug?
As with any other drug, the data available for the analysis of a vaccine's adverse effects are often less robust than those available for analysis of its efficacy. When all factors are taken into account, a vaccine sometimes clearly represents a therapeutic advance.
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ADVERSE EFFECTS
Pregabalin (Lyrica° and other brands): abuse and dependence on the increase
Given the increase in cases of pregabalin abuse and dependence, the need for prescription should be kept under regular review, as well as any potentially dangerous combinations with other drugs.
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Smoking cessation induces toxic dose levels of certain drugs
Toxic dose levels (alias overdose) of certain drugs have been observed a few weeks after the patient stopped smoking. Some had serious consequences, especially those involving a drug with a narrow therapeutic index.
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COMING SOON
Enjoy these features, and more, in our upcoming issues
- Romosozumab in severe postmenopausal osteoporosis: not acceptable
- Treosulfan in preparation for haemopoietic stem cell transplantation
- Fingolimod: avoid its teratogenic effect
- Covid-19: review of 2020
- The 2020 Prescrire Awards...
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