E-drug: Optimal dosing strategy for statins (cont'd)
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[Please 'repair' the several url's mentioned in this posting. HH]
Should anyone be put on statins for secondary prevention? Response
to Therapeutics Initiative Letter #49?
Sharon Smith
Writer, editor, researcher and statin activist
1005, 10101 Saskatchewan Drive
Edmonton Alberta T6E 4R6
Canada
e-mail:<ns_river@yahoo.ca>
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Statin-associated myopathy.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=Pub
Med&list_uids=12672737&dopt=Abstract Thompson PD, Clarkson P,
Karas RH.
Preventive Cardiology and Cardiovascular Research, Division of
Cardiology, Hartford Hospital, Hartford, Conn 06102, USA.
pthomps@harthosp.org "recent evidence suggests that statins reduce
the production of small regulatory proteins that are important for
myocyte maintenance"
To the FDA: "Citizen Petition To Change The Labeling For All Statin
Drugs (Mevacor, Lescol, Pravachol, Zocor, Lipitor, And Advicor)
Recommending Use Of 100-200mg Per Day Of Supplemental
Co-Enzyme Ql0 to Reduce the Risk Of Statin-Induced Myopathies
(Including Cardiomyopathy and Congestive Heart Failure)," by Dr.
Julian Whitaker, MD:
http://www.fda.gov/ohrms/dockets/dailys/02/May02/052902/02p-0244-
cp00001-01-vol1.pdf or as html:
http://216.239.33.100/search?q=cache:4qAiX-YbZLYC:www.fda.gov/
ohrms/dockets/dailys/02/May02/052902/02p-0244-cp00001-01-vol1.p
df+Statin-Induced+Cardiomyopathy+Introduction+To+The+Citizen%2
7s+Petition+On+Statins&hl=en&ie=UTF-8 Statin Depletion of CoQ10
is linked to heart problems.
Exhibit A of FDA Petition: "The clinical use of HMG CoA-reductase
inhibitors (statins) and the associated depletion of the essential
co-factor coenzyme Ql0; a review of pertinent human and animal
data."
by Dr. Peter Langsjoen MD:
http://www.fda.gov/ohrms/dockets/dailys/02/May02/052902/02p-0244-
cp00001-02-Exhibit_A-vol1.pdf
Examples of the heart problems associated with statin depletion of
CoQ10.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=Pub
Med&list_uids=2247468&dopt=Abstract Lovastatin decreases
coenzyme Q levels in humans. Proc Natl Acad Sci U S A. 1990
Nov;87(22):8931-4. PMID: 2247468 [PubMed - indexed for MEDLINE]
A 1990 study showing depletion of CoQ10 by Lovastatin includes
descriptions of cardiac patients.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=Pub
Med&list_uids=11479481&dopt=Abstract A 2001 discussion on "The
effect of pravastatin and atorvastatin on coenzyme Q10"
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