E-drug: RE: Dipyrone
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Dear E-Druggers:
Dipyrone is considered one of the safest drugs in the NSAID's group. It has
the lowest relative OR for gastrointestinal bleeding, it has no
antiinflammatory action, many of the undesirable effects associated with
NSAID's are absent when you use this drug.
The greatest risk with dipyrone is the agranulocytosis, that
is one of its known adverse reactions.
In recent reviews of the initial studies, which "rang" the alarm bell about
this drug's indesirable effects, the reliability of primary data is
questioned.
Incidence rate of agranulocytosis by any disease is 5 x 1 000 000 patients,
dipyrone produces 16% of these cases with a 5% mortality rate. So the
problem is not so big as was thought at the beginning.
In Cuba, dipyrone, has never been forbidden, and currently is in our basic
drug list. Some European countries have reintroduced dipyrone in their basic
drug list.
Best regards
Dr J. A. Furones, MD
Senior Pharmacology Lecturer
Dr Rogelio Fernandez, Pharmacist, PhD
Frank Debesa, B Sc, Pharmacist
Pharmacoepidemiology Development Center
44 No 502 esq 5a Ave
Miramar, Playa
Havana. Cuba
CP 11300
E-Mail: cdf@infomed.sld.cu
Fax: (537) 24-7227
Phone: (537) 24-0924
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