E-DRUG: Tinidazole versus Metronidazole for H pylori eradication
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Highly esteemed e-druggers,
I consider this recent experience worth sharing.
Sequel to the non-availability of Metronidazole
Tablets in the hospital pharmacy stores for reasons
best known to the institution's Procurement Officer,
Management and the supplier (since the medicine is
freely available in the local community retail drug
outlets - both pharmacies and patent medicine vendors'
shops) and the discovery of 3x (10x10) Tablets of
Tinidazole 500mg in the Central Drug Stores, I
decided upon consultation with the Chief
Pharmacist-in-charge to take up the stock and
encouraged my unit's Pharmacists to substitute 2g
once daily for 3 days of the latter for 200-400mg
three times daily of the former, both known to be
equally effective nitro-imidazole anti-protozoals
against Trichomonas vaginalis, Entamoeba histolytica,
as well as Gardia intestinalis.
The available stock was exhausted in a matter of days,
and patients' responses were quite satisfactory, with
no note-worthy serious adverse reaction.
My Pharmacists got so excited that they wondered if
such a substitution could also work for eradication of
Helicobacter pylori infection in peptic ulcer disease,
as part of the currently promoted multi-drug
therapeutic regimen, a poser to which I require
contributions from more experienced and knowledgeable
e-druggers.
Thank you, and stay blessed.
Fondest regards from
Olutayo Adetokunbo Moronkeji, B. Pharm., MPSN, MNIM, CEDP (Hons.)
Deputy Chief Pharmacist, Obafemi Awolowo University
Teaching Hospitals Complex (OAUTHC), Ile-Ife &
Head of Pharmacy, OAUTH Wesley Guild Hospital, Ilesa Unit
NIGERIA.