E-DRUG: Five Lancet articles on antibiotic resistance free
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published: November 18, 2015
http://www.thelancet.com/series/antimicrobials-access-and-sustainable-effectiveness
Executive Summary
This Series examines the access and sustainable effectiveness of antimicrobials. The first two papers provide an insight into the mechanisms and drivers of antimicrobial resistance, its disease burden, and the potential effect of vaccines in restricting the need for antibiotics. The last three papers in the Series examine access and sustainability of antimicrobials at a more geographical level: reviewing access in low-income and middle-income countries; considering different policy domains and their effectiveness at national and regional levels to combat resistance; and identifying gaps in the current global effort to improve international collaboration and achieve key policy goals.
Antibiotics: achieving the balance between access and excess
Pamela Das, Richard Horton
DOI: http://dx.doi.org/10.1016/S0140-6736(15)00729-1
Animal production and antimicrobial resistance in the clinic
Timothy P Robinson, Heiman F L Wertheim, Manish Kakkar, Samuel Kariuki, Dengpan Bu, Lance B Price
DOI: http://dx.doi.org/10.1016/S0140-6736(15)00730-8
National action for global gains in antimicrobial resistance
Nazira Abdula, James Macharia, Aaron Motsoaledi, Soumya Swaminathan, Krishnaswamy VijayRaghavan
DOI: http://dx.doi.org/10.1016/S0140-6736(15)00668-6
Access to effective antimicrobials: a worldwide challenge
Ramanan Laxminarayan, Precious Matsoso, Suraj Pant, Charles Brower, John-Arne Røttingen, Keith Klugman, Sally Davies
DOI: http://dx.doi.org/10.1016/S0140-6736(15)00474-2
Understanding the mechanisms and drivers of antimicrobial resistance
Alison H Holmes, Luke S P Moore, Arnfinn Sundsfjord, Martin Steinbakk, Sadie Regmi, Abhilasha Karkey, Philippe J Guerin, Laura J V Piddock
DOI: http://dx.doi.org/10.1016/S0140-6736(15)00473-0
Maximising access to achieve appropriate human antimicrobial use in low-income and middle-income countries
Marc Mendelson, John-Arne Røttingen, Unni Gopinathan, Davidson H Hamer, Heiman Wertheim, Buddha Basnyat, Christopher Butler, Göran Tomson, Manica Balasegaram
DOI: http://dx.doi.org/10.1016/S0140-6736(15)00547-4
Exploring the evidence base for national and regional policy interventions to combat resistance
Osman A Dar, Rumina Hasan, Jørgen Schlundt, Stephan Harbarth, Grazia Caleo, Fazal K Dar, Jasper Littmann, Mark Rweyemamu, Emmeline J Buckley, Mohammed Shahid, Richard Kock, Henry Lishi Li, Haydar Giha, Mishal Khan, Anthony D So, Khalid M Bindayna, Anthony Kessel, Hanne Bak Pedersen, Govin Permanand, Alimuddin Zumla, John-Arne Røttingen, David L Heymann
DOI: http://dx.doi.org/10.1016/S0140-6736(15)00520-6
International cooperation to improve access to and sustain effectiveness of antimicrobials
Christine Årdal, Kevin Outterson, Steven J Hoffman, Abdul Ghafur, Mike Sharland, Nisha Ranganathan, Richard Smith, Anna Zorzet, Jennifer Cohn, Didier Pittet, Nils Daulaire, Chantal Morel, Zain Rizvi, Manica Balasegaram, Osman A Dar, David L Heymann, Alison H Holmes, Luke S P Moore, Ramanan Laxminarayan, Marc Mendelson, John-Arne Røttingen
DOI: http://dx.doi.org/10.1016/S0140-6736(15)00470-5
Lancet - Summary
Securing access to effective antimicrobials is one of the greatest challenges today. Until now, efforts to address this issue have been isolated and uncoordinated, with little focus on sustainable and international solutions. Global collective action is necessary to improve access to life-saving antimicrobials, conserving them, and ensuring continued innovation. Access, conservation, and innovation are beneficial when achieved independently, but much more effective and sustainable if implemented in concert within and across countries. WHO alone will not be able to drive these actions. It will require a multisector response (including the health, agriculture, and veterinary sectors), global coordination, and financing mechanisms with sufficient mandates, authority, resources, and power. Fortunately, securing access to effective antimicrobials has finally gained a place on the global political agenda, and we call on policy makers to develop, endorse, and finance new global institutional arrangements that can ensure robust implementation and bold collective action.
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Lucas F.M. van der Hoeven
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Lucas <lucas.van.der.hoeven@cbsm.nl>