E-DRUG: Independent Drug and Healthcare Newsletter for July-August 2021
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Independent information by and for healthcare professionals
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In Prescrire's Spotlight this month :
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FEATURED REVIEW
Low-dose methotrexate: 2-year follow-up of adverse events
Low-dose methotrexate is a useful first-line treatment in a range of autoimmune diseases such as rheumatoid arthritis. A 2-year follow-up of several thousand patients provides new estimates of the frequency of adverse events.
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FREE DOWNLOAD
In the July issue of Prescrire International: fusidic acid + betamethasone valerate cream (Dermafusone°) and infected atopic eczema
Atopic eczema is sometimes complicated by infection, most often caused by Staphylococcus aureus ("golden staph"), with the development of pustules and crusting. How do Prescrire's editors rate fusidic acid + betamethasone valerate cream in this situation?
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EDITORIAL
Show your face!
Are there any amphetamine derivatives still on the market? Yes, and healthcare professionals would do well to be able to spot them in order to anticipate their effects, in particular their adverse effects, and especially their cardiovascular adverse effects.
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Iodine during pregnancy: supplementation should not be systematic
Iodine-containing food supplements have no proven benefits for pregnant women, and can be dangerous for the unborn child.
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Human papillomavirus vaccine (Gardasil 9°): useful in young men too
The 9-valent human papillomavirus vaccine (Gardasil 9°) probably has a positive harm-benefit balance in the men who are the most at risk of developing papillomavirus-related cancer.
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Proton pump inhibitors: avoid unjustified risks, and know how to "deprescribe"
It is better to be aware of the harms of prolonged use of proton pump inhibitors (drugs for gastrointestinal disorders), and to avoid prescribing or advising these drugs too readily.
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Food supplements: too readily authorised and sometimes dangerous
Several factors contribute to a major ongoing confusion between food supplements and medicinal products. Large numbers of safety signals increasingly indicate the need for caution, whereas the benefit of taking food supplements remains uncertain.
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COMING SOON
Viral vector covid-19 vaccine ChAdOx1-S .. Siponimod and multiple sclerosis Drug induced QT prolongation .. Stopping antidepressant therapy .. Prescrire's annual drug packaging review...
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