E-DRUG: Prescrire Independent Drug and Healthcare Newsletter for June 2019
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In Prescrire's Spotlight this month
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FEATURED REVIEW Methylphenidate (Ritalin° and other brands) during pregnancy: teratogenic and fetotoxic, with concerns about long-term effects
Methylphenidate is an amphetamine-like psychostimulant used in attention deficit hyperactivity disorder (ADHD). Recent studies have revealed important data about the consequences of in utero exposure to methylphenidate for the unborn child, in the short and long term.
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FREE DOWNLOAD In the June issue of Prescrire International - Treatment of scabies: 5% permethrin cream or oral ivermectin?
In patients with scabies, topical application of 5% permethrin cream and oral ivermectin have a similar harm-benefit balance. How do these two treatment options stack up?
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Atrial fibrillation: apixaban (Eliquis°) as an alternative to warfarin (Coumadin° and other brands) in some situations
When atrial fibrillation warrants the use of an anticoagulant, the anti-vitamin K warfarin (Coumadin° and other brands) is still the best long-term evaluated oral anticoagulant. The anti-Xa apixaban (Eliquis°) is an alternative in some situations.
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Ginkgo biloba: to be avoided due to severe adverse effects
In practice, it is better to avoid this plant, which has no proven efficacy and exposes patients to serious adverse effects, including convulsions.
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Useful tips for informing patients about risks
The vast majority of patients would like more explanations in order to better understand their state of health and to participate in therapeutic choices that affect them. How can healthcare professionals deliver this?
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ADVANCING HEALTHCARE POLICY Orphan drugs: affordability is at risk due to abuse of orphan drug incentives
In its response to the public consultation on the European Commission's guideline on orphan drugs, Prescrire encourages the Commission to pay particular attention to the extreme profitability of certain orphan products, and to better consider alternative treatments such as off-label use or magistral formulations.
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COMING SOON Enjoy these features, and more, in our upcoming issues
Tiotropium and severe asthma, from six years of age * Emtricitabine + tenofovir disoproxil for prevention of HIV infection in adolescents * Fentanyl and other opioids: hyperalgesia * Psychotic episodes: which oral neuroleptic should be chosen? * 2018 drug packaging review...
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