[e-drug] Independent Drug and Healthcare Newsletter for May 2018

E-DRUG: Independent Drug and Healthcare Newsletter for May 2018
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Independent Drug & Healthcare Newsletter from the non-profit journal Prescrire International

Newsletter, May 2018

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In Prescrire's Spotlight this month
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FEATURED REVIEW Metopimazine: cardiac disorders
Metopimazine has received much less attention than domperidone in regard to its cardiovascular adverse effects, but the limited data available suggest that it probably exposes patients to a risk similar to that of domperidone.

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FREE DOWNLOAD In the May issue of Prescrire International:
Psychiatric disorders following in utero exposure to diethylstilbestrol (DES)
In utero exposure to DES results in a variety of harmful effects, including long-term harms. Psychiatric disorders reported for "DES daughters" and "DES sons" include depression, bipolar disorder, behavioural disorders and schizophrenia.

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Exploratory trials, surrogate endpoints: not a robust basis for marketing authorisation
To serve the best interests of patients, it is more necessary than ever to base marketing authorisation decisions on robust data.

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New cancer drugs: poorly evaluated, ineffective and overpriced
Many new cancer drugs are sold by drug companies at exorbitant prices, while their therapeutic benefit - when there is one - is usually modest.

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Warts: beware of acid-based wart removers
In recent years, in France and elsewhere, deep burns and necrosis, sometimes with permanent after-effects, have been reported with concentrated acid-based topical wart removers.

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