E-DRUG: Independent Drug & Healthcare Newsletter for December 2016
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Newsletter, December 2016
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N° 177 December 2016
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In Prescrire's Spotlight this month
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Diethylstilbestrol (DES): also harms the third generation
FEATURED REVIEW Diethylstilbestrol (DES) is a synthetic nonsteroidal oestrogen and endocrine disruptor that was used in the 1950s-1970s to prevent spontaneous abortion, despite its lack of proven efficacy. In utero exposure to DES can have harmful effects. What are the consequences of taking DES during pregnancy for the third generation, i.e. the children of DES children?
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In the December issue of Prescrire International: Cobimetinib (Cotellic°) and metastatic melanoma
FREE DOWNLOAD Clinical evaluation of cobimetinib in patients with metastatic or inoperable melanoma positive for the BRAF V600 mutation confirms that frontline treatment with a MEK kinase inhibitor plus a BRAF inhibitor prolongs survival by a few months, at a cost of many potentially serious adverse effects.
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Metastasised or non-operable melanomas: progress
In patients suffering from a metastasised or inoperable melanoma with or without a genetic mutation, new antitumor drugs are making it possible to prolong life for several months, at the price however of sometimes severe adverse effects.
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Operable lung cancer: chemotherapy, an option to be discussed with informed patients
In patients with non-small-cell lung cancer at an advanced but operable stage, anticancer platinum salts chemotherapy slightly prolongs life, but at the cost of many severe adverse effects.
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From the editors of Prescrire International:
Top texts of 2015-2016
FREE SPECIAL EDITION Check out this sampling of texts, selected by Prescrire's editors to introduce you to this wholly independent monthly journal, written by and for healthcare professionals
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https://user-zaoafwu.cld.bz/Top-texts-of-2015-2016
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