E-DRUG: Independent Drug & Healthcare Newsletter for October 2016
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Newsletter, October 2016
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N° 175 October 2016
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In Prescrire's Spotlight this month
Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia
FEATURED REVIEW The neuroleptics metoclopramide and domperidone have been used since the 1960s and the 1980s respectively for nausea and vomiting. Their limited efficacy and the severity of their adverse effects have slowly come to light over time. Results published in 2015 confirmed and quantified the risks of serious arrhythmia and sudden cardiac death with both drugs.
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In the October issue of Prescrire International:
Prucalopride (Resolor°) and chronic constipation in men
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For men presenting with constipation, a troublesome but usually benign disorder, prucalopride carries a disproportionate risk of cardiovascular disorders, depression and suicidal ideation. As in women, it is better to optimise the use of standard laxatives, and to avoid prucalopride altogether.
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Caring for vulnerable migrants.
A discussion-debate (in French) organised by Prescrire in Paris on 6 October 2016
Migrants, refugees: women, children and men are often in a situation of extreme vulnerability. How can they be provided with the healthcare they need, on both an emergency and a longer-term basis?
A discussion-debate in French on this important topic will be organised by Prescrire in Paris on 6 October.
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Falls in the elderly: proven benefits of exercise
Following on from others, a new trial has shown the benefits of exercise in preventing falls with trauma in elderly women.
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MedDRA and pharmacovigilance: a complex and little-evaluated tool
The standardised "Medical Dictionary for Regulatory Activities" (MedDRA) is used for coding adverse effects in clinical study reports and pharmacovigilance databases. Its complexity and its poorly evaluated performance make it susceptible to manipulation, errors of interpretation and bias.
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