E-DRUG: new Canadian GP Formulary

E-drug: new Canadian GP Formulary
----------------------------------

The second edition of Drugs of Choice: A Formulary for General Practice =
is
now out. This is an evidence based book of prescribing information
organized around diagnoses/problems for which general practitioners in
Canada would initiate therapy. This edition of the book has been expande=
d
and now includes recommendations for 177 different conditions. Besides
being available as a wire-bound book there is also a disk version (for
Windows only). The price is: book or disk CAN$19.95, book and disk
CAN$24.95 + shipping and handling costs. Payment can be made by American=

Express, Amex and Visa. I have included a list of the topics covered alo=
ng
with a sample entry. Anyone interested in getting a copy should contact:=

Canadian Medical Association
Membership Services
P.O. Box 8650
Ottawa, ON
CANADA K1G 0G8
Fax: +613-731-9013
-----------------------------------------------------------------------
Cardiovascular system
        Angina pectoris
        Atrial fibrillation
        Bacterial endocarditis-prophylaxis
        Cardiovascular disease-primary prevention
        Congestive heart failure
        Hypertension
        Hypertension and congestive heart failure
        Hypertension and diabetes
        Hypertension and dyslipidemia
        Hypertension and ischemic heart disease
        Hypertension and pregnancy
        Hypokalemia-diuretic induced
        Intermittent claudication
        Raynaud's phenomenon

Dermatology
        Acne vulgaris
        Alopecia areata
        Androgenic alopecia in men
        Bites-cat
        Bites-dog
        Bites-human
        Burns-first degree and small second degree
        Cellulitis, uncomplicated
        Dermatitis, atopic
        Dermatitis, contact
        Dermatitis, seborrheic
        Dermatophytosis
        Diabetic foot
        Diaper rash
        Furunculosis-acute and recurrent
        Head lice
        Herpes labialis
        Herpes simplex, mucocutaneous
        Herpes zoster
        Hyperhydrosis
        Impetigo, non-bullous
        Pressure ulcers
        Psoriasis
        Rosacea
        Scabies
        Sunburn
        Urticaria, chronic idiopathic
        Varicella (chickenpox)
        Venous ulcers
        Warts

Ear, nose and throat
        Angular cheilitis
        Candidiasis, oral
        Cold, common
        Cough, acute
        Dental abscess
        Ear wax
        Gingivitis
        Hiccups-persistent
        Motion sickness
        Otitis externa
        Otitis media
        Pertussis
        Pharyngitis
        Rhinitis, allergic
        Rhinitis, vasomotor
        Sinusitis, acute
        Ulcers, aphthous
        Vestibular disorders, acute

Endocrinology
        Appetite stimulation
        Diabetes, insulin-dependent
        Diabetes, non-insulin-dependent
        Hyperlipidemia
        Hyperthyroidism (Graves' disease)
        Hypothyroidism
        Obesity

Gastroenterology
        Amebiasis (Entamoeba histolytica)
        Colic, infant
        Colic, recurrent biliary
        Constipation
        Diarrhea, acute
        Diarrhea, travelers'-prophylaxis
        Dyspepsia, non-ulcer
        Gastroesophageal reflux disease
        Gastropathy, NSAID-induced
        Giardiasis (Giardia lamblia)
        Hemorroids
        Hepatitis A-prophylaxis
        Hepatitis B-post exposure prophylaxis
        Irritable bowel disease
        Lactose intolerance
        Nausea-vomiting
        Peptic ulcer disease
        Worms, intestinal

Genitourinary system
        Colic, recurrent renal
        Cystitis-pyelonephritis-adults
        Enuresis
        Epididymitis
        Impotence
        Prostatic hypertrophy, benign
        Prostatitis
        Syphilis
        Urethritis
        Urinary incontinence

Hematology
        Anemia, iron deficiency
        Anemia, pernicious

HIV
        HIV infection
        HIV-clostridium difficile colitis
        HIV-salmonella enterocolitis
        Mycobacterium avium complex (MAC)-prophylaxis
        PCP (pneumocystis carinii pneumonia)-prophylaxis
        Toxoplasmosis-secondary prophylaxis

Musculoskeletal system
        Arthritis, osteo
        Arthritis, rheumatoid
        Bursitis and tendonitis
        Fibromyalgia
        Gout
        Lyme disease-early localized disease (erythema migrans)
        Night leg cramps
        Osteoporosis, prevention and treatment
        Pain, acute-lower back
        Pain, acute-miscellaneous, soft tissue or musculoskeletal
        Strains and sprains

Neurology
        Bell's palsy
        Dementia
        Epilepsy-generalized convulsive and absence seizures
        Epilepsy-partial and secondarily generalized seizures
        Essential tremor, benign
        Headache, tension
        Ischemic stroke and transient ischemic attacks
        Meningococcal prophylaxis
        Migraine
        Neuralgia, post-herpetic
        Neuralgia, trigeminal (tic douloureux)
        Neuropathy, painful diabetic
        Parkinson's disease
        Restless legs syndrome
        Torticollis

Obstetrics and gynecology
        Cervicitis
        Contraception
        Contraception, oral-combination therapy
        Dysfunctional uterine bleeding
        Dysmenorrhea
        Mastalgia-cyclical and noncyclical
        Mastitis
        Menopausal symptoms
        Pelvic inflammatory disease
        Pre-eclampsia-primary prevention
        Pregnancy-antiemetics
        Pregnancy-preconception supplements
        Pregnancy-vitamin supplementation
        Premenstrual syndrome
        Vaginitis

Ophthalmology
        Blepharitis
        Conjunctivitis, allergic
        Conjunctivitis, bacterial
        Dry eyes

Palliative care
        Anorexia-cachexia
        Bowel care for patients on opioid analgesics
        Pain control
        Tumour-related nausea

Psychiatry and behaviour
        Alcohol dependence
        Anorexia nervosa
        Attention-deficit hyperactivity disorder
        Bulimia nervosa
        Depression
        Generalized anxiety disorder (GAD)
        Insomnia
        Mania
        Obsessive-compulsive disorder
        Panic disorder
        Schizophrenia
        Social phobia
        Substance abuse-alcohol withdrawal
        Substance abuse-benzodiazepine withdrawal
        Substance abuse-tobacco

Respiratory system
        Asthma
        Bronchitis, acute
        Chronic airflow limitation
        Pneumonia-community-acquired, adults
        Pneumonia-community-acquired, children
        Pneumonia, nursing home
        Tuberculosis prophylaxis
------------------------------------------------------------------------
DYSPEPSIA, NON-ULCER

DRUGS OF CHOICE

An empiric trial of antacids is warranted if symptoms are mild or of a
chronic nature. Symptom relief may be better with liquid preparations th=
an
with tablets.

SECOND-LINE THERAPIES<1,2,3>

Divide patients into two groups

1. Burning or pain

        H-2 antagonists

        cimetidine 400 mg, BID $0.27/d=
ay
        or
        ranitidine 150 mg, BID $0.81/d=
ay
        or
        famotidine 20 mg, BID $1.26/d=
ay
        or
        nizatidine 150 mg, BID $1.68/d=
ay

2. Bloating, fullness or heaviness

        Prokinetic agents

        metoclopramide 5-10 mg, QID (ac and hs) $0.22-0=
=2E23/day
        or
        domperidone 10 mg, QID (ac and hs) $0.71/d=
ay
        or
        cisapride 10 mg, QID (ac and hs) $2.27/d=
ay

ADDITIONAL INSTRUCTIONS AND NOTES

*Up to 60% of patients have considerable improvement of symptoms during
placebo treatment.
*Randomized trials have not demonstrated a benefit from antacids compared=

to placebo.<1,4>
*Although patients are typically divided into subgroups based on
predominant symptoms, there is no convincing data indicating that this
strategy identifies responders to a particular type of treatment.
*Although dyspepsia is a chronic condition often persisting for years the=
re
are no long-term trials of any treatment regimen.
*There is no evidence of a causal relation between H. pylori and nonulce=
r
dyspepsia.<5>
*Consider referral for additional investigation for non-responders or if
warning symptoms are present (weight loss, bleeding, vomiting).

REFERENCES

1. Holtmann G, Talley NJ. Functional dyspepsia: current treatment
recommendations. Drugs 1993;45:918-930.
2. Halter F, Miazza B, Brignoli R. Cisapride or cimetidine in the
treatment of functional dyspepsia: results of a double-blind, randomized=