E-drug: Re: Phenylbutazone availability (contd)
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Phenylbutazone is available in South Africa on doctor's prescription, under
the trade name, Inflazone. The licensed indication is "Acute exacerbations
of ankylosing spondylitis" and the package insert contains a boxed
warning stating:
"Because of potentially serious and occasionally fatal adverse effects,
use should be restricted to a maximum of 7 days and the maximum
recommended dosage should not be exceeded.
Caution against repeated short-term use is advised, due to the possible
danger of sensitisation.
Haematological disorders are potentially fatal."
Colleen Gibbon
Department of Pharmacology
University of Cape Town Medical School
Email: cgibbon@uctgsh1.uct.ac.za
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