Pesticide use for Malaria Control in Africa (17)
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Dearest Afro-Netters,
Bill, no one has ever promoted exclusive use of Insecticide-
Treated bednets (ITNs): what the evidence supports is the use of
IRS, ITNs and effective medications used in a combination that
is based on local evidence and local needs. ITNs are, by defini-
tion, treated with insecticides. Larvaciding and IRS both use
insecticides, but in small quantities and in very carefully tar-
geted ways. The evidence from many sources leads WHOs Roll Back
Malaria (RBM) department and the RBM partnership to recommend a
multi-pronged approach. And WHOs RBM department, composed of
many African and developing country scientists and scholars,
feel aerial spraying is not a good choice based on currently
available evidence.
I enclose a few peer-reviewed studies to show the impact of Bed-
Nets, just below. The first 5 with abstracts, the rest as refer-
ences widely available.
By the way, just so that people know my predispositions... I
have a degree in nursing (22 years experience), and an MBA --
not very socialist, I am afraid -- and am completing an MSc
in Development Economics. I worked for WHO from 1999 to 2005,
with my last post as a member of the Roll Back Malaria Secre-
tariat. Most of my experience has been in working with Minis-
tries of Health and Finance in Africa to develop national health
plans (e.g. for malaria control), and get them funded and imple-
mented. My agenda is to reduce preventable death and illness as
rapidly as possible, using what works and is appropriate within
the context of developing countries, as defined by national ex-
perts and leaders.
Most kind regards,
Tom OConnell
mailto:tsoconnell2@yahoo.com
--
REFERENCES on IMPACT OF BEDNETS
1. Impact on malaria morbidity of a programme supplying insec-
ticide treated nets in children aged under 2 years in Tanzania:
community cross sectional study. Salim Abdulla, Joanna Arm-
strong Schellenberg, Rose Nathan, Oscar Mukasa, Tanya Marchant,
Tom Smith, Marcel Tanner, and Christian Lengeler, BMJ 2001 322:
270-2;
ABSTRACT:
Ownership of nets increased rapidly (treated or not treated
nets: from 58% to 83%; treated nets: from 10% to 61%). The mean
haemoglobin level rose from 80 g/l to 89 g/l in the study chil-
dren in the successive surveys. Overall, the prevalence of anae-
mia in the study population decreased from 49% to 26% in the two
years studied. Treated nets had a protective efficacy of 62%
(95% confidence interval 38% to 77%) on the prevalence of para-
sitaemia and of 63% (27% to 82%) on anaemia. CONCLUSIONS: These
results show that nets treated with insecticide have a substan-
tial impact on morbidity when distributed in a public health
setting.
2. Efficacy of permethrin-treated bed nets in the prevention of
mortality in young children in an area of high perennial malaria
transmission in western Kenya. Phillips-Howard PA, Nahlen BL,
Kolczak MS, Hightower AW, ter Kuile FO, Alaii JA, Gimnig JE,
Arudo J, Vulule JM, Odhacha A, Kachur SP, Schoute E, Rosen DH,
Sexton JD, Oloo AJ, Hawley WA. Division of Parasitic Diseases,
National Center for Infectious Diseases, Centers for Disease
Control and Prevention, Atlanta, Georgia 30341, USA.
ABSTRACT:
A group-randomized controlled trial of insecticide (permethrin)-
treated bed nets (ITNs) was conducted in an area of high peren-
nial malaria transmission in western Kenya to test the effect of
ITNs on all-cause mortality in children 1-59 months of age. ITNs
prevent approximately one in four infant deaths in areas of in-
tense perennial malaria transmission, but their efficacy is com-
promised if re-treatment is delayed beyond six months. (this
will be less a factor as Long-Lasting nets are used)
3. Bed nets for the prevention of malaria and anaemia in preg-
nancy. Dolan G, ter Kuile FO, Jacoutot V, White NJ, Luxemburger
C, Malankirii L, Chongsuphajaisiddhi T, Nosten F.; Shoklo Ma-
laria Research Unit, Mae Sod, Thailand.
ABSTRACT:
Women in 3 adjacent study sites were allocated at random to re-
ceive either a single size permethrin-impregnated bed net (PIB),
a non-impregnated bed net (NIB), or to a control group who used
either their own family size non-impregnated bed net (FNIB) or
no net. Although the overall effect of bed nets on patent para-
sitaemia was marginal, they were associated with a significant
reduction in maternal malaria-associated anaemia.(Shows that re-
duction in parasite load, even if not perfect, has big impact on
morbidity and mortality).
4. Impact of permethrin-treated bed nets on the incidence of
sick child visits to peripheral health facilites". PENELOPE A.
PHILLIPS-HOWARD, BERNARD L. NAHLEN, KATHLEEN A. WANNEMUEHLER,
MARGARETTE S. KOLCZAK, FEIKO O. TER KUILE, JOHN E. GIMNIG, KRIS
OLSON, JANE A. ALAII, AMOS ODHACHA, JOHN M. VULULE, AND WILLIAM
A. HAWLEY;
ABSTRACT
During a randomized controlled trial of insecticide (perme-
thrin)-treated bed nets (ITNs) in an area with intense malaria
transmission in western Kenya, we monitored 20,915 sick child
visits (SCVs) by children less than five years of age visiting
seven peripheral health facilities. The SCVs were monitored over
a four-year period both before (19951996) and during the inter-
vention (19971998). Results are used to estimate the effect of
ITNs on the burden of malaria in this community and to evaluate
the potential role of these facilities in assessment of the im-
pact of large-scale public health interventions. Compared with
baseline, a 27% greater reduction in the incidence of SCVs was
seen in ITN villages than in control villages (37% versus 10%; P
= 0.049). A similar reduction was observed in SCVs diagnosed as
malaria (35% reduction in ITN villages versus 5% reduction in
controls; P = 0.04).
5. Effect of permethrin-treated bed nets on the spatial distri-
bution of malaria vectors in western Kenya. Gimnig JE, Kolczak
MS, Hightower AW, Vulule JM, Schoute E, Kamau L, Phillips-Howard
PA, ter Kuile FO, Nahlen BL, Hawley WA.; Am. J. Trop. Med. Hyg.,
68(4 suppl), 2003, pp. 115-120
ABSTRACT
The effect of insecticide (permethrin)-treated bed nets (ITNs)
on the spatial distribution of malaria vectors in neighboring
villages lacking ITNs was studied during a randomized controlled
trial of ITNs in western Kenya. Reduction in mosquito popula-
tions in villages lacking ITNs was most apparent in compounds
located within 600 meters of intervention villages. Sporozoite
infection rates decreased in control areas following the intro-
duction of ITNs (P < 0.001 for both species), but no spatial as-
sociation was detected between sporozoite rates and distance to
nearest intervention village. We conclude that high coverage of
ITNs is associated with a community-wide suppression of mosquito
populations that is detectable in neighboring villages lacking
ITNs, thereby affording individuals residing in these villages
some protection against malaria.
6. Nevill CG, Some ES, Mungala VO, Mutemi W, New L, Marsh K,
Lengeler C, Snow RW, 1996. Insecticide-treated bednets reduce
mortality and severe morbidity from malaria among children on
the Kenyan coast. Trop Med Int Health 1: 139146.
7. Habluetzel A, Cuzin N, Diallo DA, Nebie I, Belem S, Cousens
SN, Esposito F, 1999. Insecticide-treated curtains reduce the
prevalence and intensity of malaria infection in Burkina Faso.
Trop Med Int Health 4: 557564
8. Hawley WA, Phillips-Howard PA, ter Kuile FO, Terlouw DJ, Vu-
lule JM, Ombok M, Nahlen BL, Gimnig JE, Kariuki SK, Kolczak MS,
Hightower AW, 2003. Community-wide effects of permethrin-treated
bed nets on child mortality and malaria morbidity in western
Kenya. Am J Trop Med Hyg 68(Suppl 4): 121127.
9. ter Kuile FO, Terlouw DJ, Kariuki SK, Phillips-Howard PA,
Mirel LB, Hawley WA, Friedman JF, Shi YP, Kolczak MS, Lal AA,
Vulule JM, Nahlen BL, 2003. Impact of permethrin-treated bed
nets on malaria, anemia and growth in infants in an area of in-
tense perennial malaria transmission in western Kenya. Am J Trop
Med Hyg 68(Suppl 4): 6877