E-DRUG: Proton Pump Inhibitors - Adverse effects (2)
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[Thank you Rokuro for your fast contribution of additional information. BS]
I would like to introduce a past issue on PPI:
"H.pylori eradication may shorten life span: Gastric cancer risk decreases, but incidence of C.difficile infection and pneumonia increase instead"
http://www.npojip.org/english/MedCheck/Med%20Check-TIP%2001-4-25.pdf
We pointed out the possibility of increase mortality risk from RCTs.
One more point is the mechanisms of harmful effect of PPIs.
eIt is generally believed that secretion of gastric acid is suppressed by PPIs as the mechanisms of pneumonia caused by PPI use. However, more important mechanisms, V-type proton pump (V-ATPase) should be discussed [3-5].
PPIs inhibit not only the gastric proton pump but also V-type proton pump which are found in almost all cells in the body, including alveolus type II cells [12], macrophages (including the alveolar macrophages) [13], neutrophils, kidney cells, osteoclasts, testicular cells and plasma membrane of certain neoplastic cells. It plays a very important role in maintaining normal functions of these cells: acidification of urine, bone resorption, appropriate pH maintenance in the immune system cell and sperm maturity.
Please see original post also
http://www.npojip.org/english/MedCheck/Med%20Check-TIP%2009-12-27.pdf (No 9: 2017)
and
http://www.npojip.org/english/MedCheck/Med%20Check-TIP%2001-4-25.pdf
(No1:2015) - mentioned above for details.
Best regards
Rokuro
Rokuro Hama
Med Check TIP
Japan Institute of Pharmacovigilance
"HAMA, Rokuro " <gec00724@nifty.com>