E-DRUG: Consilium Webinar 10.11. The waste in futile oncology drug
development
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Consilium-scientific.org
Thursday, November 10th, 5pm, London time
The Zoom link will be sent on the day of the seminar
A reported attrition rate of >90% for the development of oncology drugs
results in a substantial waste of resources and disappointment for all
parties involved, particularly patients. This talk presents our research
where we aimed to estimate the costs of the 183 clinical trials of 16
agents targeted to the insulin growth factor 1 receptor (IGF1R), none of
which exhibited activity permitting approval for clinical use. This is the
first attempt to quantify drug development cost focussing on a specific
target.
Lecturer: Jon Hickman, PhD:
Prof Hickman is an internationally known scientist who trained in pharmacy
at Aston University. After a postdoctoral fellowship at the Institute of
Cancer Research London, he held University posts in molecular pharmacology
in Liverpool, Birmingham and Manchester and as a visiting scientist at Yale
University. As a Director of the Cancer Research Campaign?s (now CRUK)
Experimental Chemotherapy group in Birmingham he was lead pharmacologist
for the discovery of the drug Temozolomide used to treat brain tumours. He
worked on the role of apoptosis in determining anticancer drug sensitivity
and resistance, particularly the role of the BCL-2 family of proteins. He
talked about his work on apoptosis in 1998 at the invitation of the Nobel
Forum in Stockholm. He was invited again to speak at a Nobel Symposium in
2018, this time on personalised cancer medicine. Professor Hickman moved to
Paris in 2000 to direct cancer drug discovery at Servier. He retired in
2010 and then coordinated the European Union Innovative Medicines
Initiative (IMI) consortium PREDECT (www.predect.eu). In March 2018, he
co-organised an international meeting at the Francis Crick Institute
entitled 'The Challenges Preventing Cancer Cure."
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